The Science Behind Enamel & Co. Clinically Formulated, Dentist-Owned
Twenty years of clinical practice distilled into one system. Built on biomimetic science, not marketing trends. Every ingredient chosen for mechanism, not label claims.
- Dentist-Owned & Formulated
- Nano-Hydroxyapatite Formula
- EnamelSync™ Peptide Technology
- Fluoride-Free & SLS-Free
- Exclusively at Participating Dental Offices
- Clinically Tested
The Science
Built on 20 Years of Clinical Knowledge
- Featuring EnamelSync™ Peptide Technology — Proprietary Formula
01
Nano-Hydroxyapatite
The same mineral that makes up 97% of tooth enamel. Our nano-sized particles penetrate micro-fissures to remineralize from within — the same mechanism your body uses naturally.
02
EnamelSync™ Peptide Technology
Powered by Palmitoyl Tripeptide-1 — a clinically studied signal peptide that stimulates collagen synthesis in gum tissue. It reduces gum inflammation, supports soft tissue healing, and helps combat gum recession by restoring firmness to the gingival tissue. While nano-hydroxyapatite rebuilds the tooth, EnamelSync™ rebuilds the foundation around it.
03
Fluoride-Free Formula
We chose nano-hydroxyapatite over fluoride because the science is compelling and the safety profile is unmatched. No neurotoxicity concerns. Safe for the whole family.
04
SLS & Paraben Free
No sodium lauryl sulfate, no parabens, no artificial dyes. Every ingredient in Enamel & Co. was selected by dentists who would use it on their own families.
05
Airless Pump Technology
Our 2oz airless pump preserves formula integrity by eliminating air and bacteria exposure. Every pump delivers a precise, contamination-free dose — every time.
All actives at clinically validated concentrations • No fairy dusting
02 / MECHANISM OF ACTION
How It Works 3 Steps to Remineralization
- STEP 01
Cleanse
Gentle, non-ionic surfactants lift biofilm without stripping salivary proteins. pH-balanced to 7.2 to halt acid attack.
- Coconut-derived cleansers
- No SLS, no disruption
- Preserves pellicle layer
- STEP 02
Repair
EnamelSync™ peptides self-assemble in lesion, n-HAp infiltrates scaffold. Calcium and phosphate ions deposit, rebuilding subsurface density.
- Peptide scaffold forms in 2 min
- n-HAp integrates, not just coats
- Subsurface remineralization
- STEP 03
Protect
Reconstructed enamel forms acid-resistant layer. Smooth surface resists plaque adhesion, maintains gloss and reduces sensitivity.
- Acid resistance +32%
- Reduces hypersensitivity
- Gloss retention
Clinical note: Mechanism validated via transverse microradiography and SEM analysis. Full occlusion of tubules observed at day 14 with twice-daily use.
03 / COMPARATIVE SCIENCE
EnamelSync™ vs Everything Else
Most toothpaste markets ingredients. We engineer mechanism. Here’s how our approach differs from conventional fluoride, standard n-HAp, and peptide-free formulas.
- KEY DIFFERENTIATOR
Only system combining scaffold + mineral. Peptides guide, n-HAp builds.
| ENAMEL & CO. EnamelSync™ + 20% n-HAp | CONVENTIONAL Fluoride 1450ppm | STANDARD n-HAP n-HAp only | |
|---|---|---|---|
| MECHANISM | Scaffold-guided remineralization | Fluorapatite conversion (surface) | Mineral deposition (no scaffold) |
| LESION DEPTH | Subsurface to 120µm | Surface only ~20µm | Surface to 50µm |
| ACID RESISTANCE | +32% vs baseline | +18% (soluble in acid) | +24% |
| SENSITIVITY | Tubule occlusion + peptide seal | Temporary nerve block | Partial occlusion |
| SAFETY PROFILE | Non-toxic, biomimetic | Systemic if ingested, FDA warning | Safe, but low efficacy alone |
| BASED ON IN-VITRO TRANSVERSE MICRORADIOGRAPHY, N=60 LESIONS | PEER-REVIEWED DATA | ||
03 / COMPARATIVE SCIENCE
Every ingredient,with intention.
No fillers. No fluoride. No artificial foaming agents. Just five clinically-backed actives doing exactly what they should.
Nano-Hydroxyapatite
nHAp 10%
Remineralizes enamel & reduces sensitivity — the biomimetic core.
Xylitol
Birch-derived
Inhibits S. mutans, balances pH, prevents cavities.
Zinc Citrate
Mineral
Controls plaque buildup and freshens breath at the source.
Aloe Vera + Coconut Oil
Soothing base
Gently cleanses without SLS, supports gum health.
Natural Mint Oils
Spearmint & Peppermint
Clean taste, no artificial sweeteners or masking agents.
05 / WHY DENTIST OWNED?
Formulated like a prescription, not a commodity.
Dentist-Formulated
Created by practicing dentists, not a marketing lab. Dosage, pH and texture tested chair-side.
Safe for Family
Fluoride-free, SLS-free, non-toxic if swallowed. Gentle enough for kids, effective for adults.
Airless Purity
Airless pump protects actives from oxidation & bacteria. No jar, no contamination, every dose fresh.